白藜蘆醇分子環(huán)糊精包合物的研究.pdf

1、河北農(nóng)業(yè)大學(xué)碩士學(xué)位論文白藜蘆醇分子環(huán)糊精包合物的研究姓名：安偉娟申請學(xué)位級別：碩士專業(yè)：農(nóng)產(chǎn)品加工及貯藏工程指導(dǎo)教師：鎖然2009-06-13The Study of inclusion complexes of resveratrol with Author:An Wei-juan Tutor: SUO Ran Major: Primary Product Processing and Storage Engineering AB

2、STRACT It is well known that resveratrol is a kind of phytoalexin which has the properties of antioxidant and the function of lowering the prevanlence of coronary heart disease. In the present researches, it is reported

3、that resveratrol is a new promosing anticancer drug with the cancer chemopreventive activity that represent in three major stages of carcinogenesis such as anti-initiation, anti-promotion and anti-progression activities.

4、 The application of resveratrol is limited and bioavailability of resveratrol is lower due to its poor solubility and unstability under intensive UV light. So it is important to enhance the resveratrol of solubility in w

5、ater and stability to wide its applitication. Cyclodextrins (CDs) are a kind of larger-ring compounds shaped like truncated cone. Their unique structure of interior hydrophobic cavity can include guestes that local in it

6、s special cavity or between its self-aggregation. They have exterior hydrophilic surface and thus water solubility of the poorly soluble guests by inclused can be promoted. α-cyclode- xtrin (α-CD) and β-cyclodextrin (β-C

7、D) are wide used for enhancing the solubility. Beca- use of low solubility, β-CD is often improved by introducing modified groups into edges to extend its application. One of its derivatives often used as solubility incr

8、easer is hydroxyl- propyl-β-cyclodextrin (HP-β-CD), which has features of low toxicity and good water sol- ubility. In this paper, the complexation of poorly water-soluble resveratrol with HP-β- CD were investigated. (1)

9、 The inclusion complexes were prepared by freeze-drying method. The optimum preparation condition was studied by orthogonal test with encapsulation rate as the index of evaluation: the ratio of Resveratro to HP-β-CD 1 :

10、2, inclusion temperature 30℃, inclu- sion time 60 minutes. It had been preliminarily proved that the inclusion complexes of Resveratrol-hydroxypropyl-β-cyclodextrin were formed.The rate of inclusion satisfied us. (2) The

11、 inclusion complexes of Resveratrol-hydroxypropyl-β-cyclodextrin were character- rized by differential scanning calorimetry, IR and UV absorption spectrum. It was confir- med that the inclusion complexes of Resveratrol-

12、hydroxypropyl -β- cyclode- xtrin were formed. (3) The hydroxypropyl-β-cyclodextrin is very stable in the alkalinity medium, but can be decomposed by the strong acid, therefore used the hydrochloric acid to damage on incl