肺鱗癌中TGF-β-,1-的表達與上皮間質(zhì)轉(zhuǎn)化關系的初步研究.pdf

1、南昌大學碩士學位論文肺鱗癌中TGFβ的表達與上皮間質(zhì)轉(zhuǎn)化關系的初步研究姓名：萬安云申請學位級別：碩士專業(yè)：病理學與病理生理學指導教師：熊小亮20091201AbstractABSTRACTObjective：TostudytheexpressionandrelationshipofTGF13l，Ecadherinan，VimentinandtoinvestigatethecorrelationofTGF13tinducedepithel

2、ialmesenchymaltransitionofSquamouscellCarinomaofLungMethods：60patients’clinicpathologydataandparaffinblockswerecollectedTheexpressionofTGF13l、EcadherinandVimentinwasdetectedbyMaxVision刑immunohistochemieialmethodResults：l

3、、TheexpressionrateofTGF一13lproteinwassignificantlyhigherinSquarnous—cellCarinomaofLungtissuesthaninadjacentnoncanceroustissues(333％W166％，PO05)；TheexpressionofTGF一13linⅡI～ⅣofTNMstagingwashigherthanthatinI～lIofCanCCTtissue

4、Metastasisgroupwashi曲erthanmetastasesgroupLowdifferentiategroupwashigherthanmiddleandhi曲group(PO05)，whichwasnotrelatedwithgenderageandtumorsize2、TheexpressionrateofEcadherinproteinwassignificantlylowerinSquamous—cellCari

5、nomaofLungtissuesthaninadjacentnOllcanccroustissues(533％倦80％，PO01)；TheexpressionofE—cadherininmetastasisgroupWaslowerthanmetastasesgroup，andmiddleandhi曲differentiategroupwerelowerthanlowdifferentiategroupTheexpressionwas

6、n’trelatedwithgenderage，tumorsizeandTNMstaging3、TheexpressionrateofVimentinproteinwashigherinSquamous—cellCarinomaofLungtissuesthaninadjacentnon—canceroustissues(461％俗O％，P0O1)TheexpressionofVimentininmetastasisgroupWaShi

7、gherthanmetastasesgroupTheexpressionofVimentininIII～ⅣofTNMstagingWashigherthanthatinI～IIofCanCel“tissue(PO05)，whichWaSh’trelatedwithgenderage，tumorsizeanddifferentiation4、InSquarnous—cellCarinomaofLung，theexpressionofTGF

8、一13lWasnegativelycorrelatedtothatofE—cadherin(嚴O26，P=0046)，butpositivelycorrelatedtothatofVimentinprotein(嚴0331，P=0011)；inaddition，theexpressionofE—cadherinWasnocorrelatedtothatofVimentinprotein(嚴一0004，P=0973)Conclusion：