大劑量岷當歸配伍川芎對腦缺血再灌注損傷大鼠腦組織中ICAM-l、IL-1β和COX-2mRNA的影響.pdf

1、分類號：密級：碩士研究生學位論文論文題目（中文）大劑量岷當歸配伍川芎劑量岷當歸配伍川芎對腦缺血再灌注腦缺血再灌注損傷損傷大鼠大鼠腦組織中腦組織中ICAMICAMl、ILIL1β和β和COXCOX2mRNA2mRNA的影響的影響論文題目（外文）EffectEffectofofalargedosalargedoseofofAngelicasinensisAngelicasinensisChuanxiongonChuanxiongontheE

2、xpressionoftheExpressionofICAMICAMl、ILIL1β、β、COXCOX2mRNAinBrainmRNAinBrainTissuesTissuesofofCerebralCerebralischemiaischemiaReperfusioninjuryeperfusioninjuryRatRat研究生姓名左毅學科、專業(yè)方劑學方劑學研究方向心腦血管疾病治法與方劑的實驗及臨床研究心腦血管疾病治法與方劑的實驗及臨

3、床研究導師姓名、職稱李妍怡教授李妍怡教授論文工作起止年月20112011年3月至20122012年3月論文提交日期20122012年3月論文答辯日期20122012年5月學位授予日期20122012年6月目錄目錄中文摘要..............................................................................................................

4、........1Abstract...............................................................................................................................2前言.........................................................................

5、...........................................................5一、立題依據(jù)....................................................................................................................71.祖國醫(yī)學對腦缺血再灌注損傷的認識及研究現(xiàn)狀..............

6、...............................71.1中醫(yī)對“中風”病名及病位的認識..........................................................71.2中醫(yī)對“中風”病因病機的認識..............................................................71.3中醫(yī)藥治療“中風”病的研究...............

7、...................................................92.現(xiàn)代醫(yī)學對腦缺血再灌注損傷的認識...............................................................122.1自由基與腦缺血再灌注損傷....................................................................12

8、2.2炎癥反應與腦缺血再灌注損傷...............................................................132.3細胞內(nèi)鈣離子超載與腦缺血再灌注損傷..............................................132.4興奮性氨基酸與腦缺血再灌注損傷.....................................................

9、..142.5細胞凋亡與腦缺血再灌注損傷...............................................................143腦缺血再灌注損傷模型研究的進展................................................................153.1動物的選擇.............................................

10、...................................................153.2局灶性腦缺血模型....................................................................................153.3全腦缺血模型.............................................................

11、...............................16二、實驗研究..................................................................................................................181.實驗材料...........................................................

12、....................................................181.1實驗動物....................................................................................................181.2實驗藥品..................................................

13、..................................................181.3主要實驗儀器及試劑................................................................................182.實驗方法....................................................................

14、...........................................182.1動物分組....................................................................................................182.2給藥方法...........................................................

15、.........................................192.3模型建立....................................................................................................192.4模型評分標準...........................................................