脊柱轉(zhuǎn)移瘤氫質(zhì)子磁共振波譜初步研究.pdf

1、青島大學碩士學位論文脊柱轉(zhuǎn)移瘤氫質(zhì)子磁共振波譜初步研究姓名：趙秀芹申請學位級別：碩士專業(yè)：影像醫(yī)學與核醫(yī)學指導教師：徐文堅林青20090607AbstractObjective：Toobserveprotonmagneticresonancespectroscopy(1HMRS)performanceofvertebraewithmetastatictumorsandhealthycontrolvertebrae，andtoquanti

2、tativelyanalyzeandevaluatethelipid／waterratio(LWR)，percentageoffat(FF％)anditscorrelationwithageofthetwogroupsofvertebralbodysMethod：①23clinicallyandpathologicallyconfirmedcaseswithspinalmetastasesand25healthycaseswereper

3、formedwithconventionalMRIby30TMR②1H—MRSimagingoftumorinvolvedvertebralbodyandL2vertebralbodywereobtainedSingleVoxelsequence(SVS)andpointresolvedspectroscopysequence(PRESS)wereselectedforspectralacquisitionofthevertebralb

4、odyR面etitiontime(TR)=2000ms，echotime(TE)=35ms，thevolumeofinterest(VOI)=lxlxlcm’2x2x2cm3，waterandfatsuppressionnotselected③1H—MRSwaveformperformanceofselectedvertebraeswereobserved④Applicatingstatisticalmethods，thefat／wat

5、erratio(LWR)，percentageoffat(FF％)anditsagecorrelationoftheinterestedvertebralbodyswerequantitativelyanalyzedcomparingthemetastatictumorgroupwithcontrolgroupResult：①Vertebral1H—MRSofmetastasesgroupandcontrolgrouphaveallsh

6、ownfortwopeaks：lipidpeakandwaterpeakComparedwiththecontrolgroup，thelipidpeakofvertebralmetastasesgroupissignificantlyreducedordisappeared，waterpeakincreased②Onvertebralmetastasesgroup，themeanLWRis003840024，andthemeanFF％i

7、s3664220％；Oncontrolgroup，themeanLWRofvertebralbodyis0644020，andthemeanFF％is37914866％；LWRandFF％ofmetastasesgrouparesignificantlylowerthanthecontrolgroup(t=147，P005andr=0151pO491005)Oncontrolgroup，themeanageis562士93，LWRand

8、FF％correlatedwithage(r=0955；pO01andro936；／9001)Conclusion：Comparedwiththehealthycontrolgroup，lH—MRSofspinalmetastasesgroupshowedsignificantlylowerordisappearedlipidpeakandhighwaterpe出，LWRandFF％valuesaresignificantlylower