山西省非綜合征性唇腭裂影響因素病例對照研究.pdf

1、山西醫(yī)科大學碩士學位論文山西省非綜合征性唇腭裂影響因素病例對照研究姓名：馬艷春申請學位級別：碩士專業(yè)：流行病與衛(wèi)生統(tǒng)計學指導教師：曲成毅20080515山西醫(yī)科大學碩士學位論文ACasecontrolStudyofNon—syndromicCleftLipandPalateinShanxiProvinceAbstractObjective：ToinvestigatethesituationofnonsyndromicCleftLipan

2、dPalateinShanxiprovincefrom1997tO2006andanalysethepossibleriskfactorsToprovidethescientificbasisforpreventingmethodsMethods：ThestudycontainstwopartsThefirstpartisdescriptivestudyTocollectthedateofmCLPin33hospitalsinShanx

3、iprovincefrom1997to2006andanalysethechangetrendofnsCLPintenyearsbytrendchi—squaretestnesecondpartiscase—controlstudyWedesignthequestionairandselect100mCLPmothersasacasegroupand200mothers塒thnormalnewbornsasacontrolgroupby

4、1：2fromJan2005toDec2006The25factorsweinvestigatewereanalysedonebyone、析t11univariatelogisticandthosethathavemeaninginstatisticswerefurtheranalysed硒mCoxregressionResultsThetotalineidenceofnsCLPinShanxiwasl946／10000Therewas

5、nosignificantlychangetrendintenyearsTheincidenceofmCLPinruralareasissignificantlyhigherthanthatinurbanareas，higherinmalethaninfemalebirthsUnivariateelogisticregressionshowedthatpermanentresidence，educationdegree，familyhi

6、storysystemicdiseases，earlypregnancyfluearlypregnancydrug，passivesmokingandbirthweighthavemeaninginstatistics(PO05)ThosefactorswereanalysedfurtherbyCoxregressionandfamilyhistoryearlypregnancydrug，passivesmoking，birthweig

7、htareconsideredriskfactors，ORvaluesare15512(95％CIforOR：2276105766)、2766(95％CIforOR：14065441)、3011(95％CIforOR：1533—5914)、2608(95％CIforOR：12755332)respectivelyandeducationdegreeispreventfactors，ORvaluesis0264(95％CIforOR：O1

8、390499)。Conclusion功eincidenceofnsCLPinShanxiwashigherthanotherprovinceinchinaandnosignificantlydeclinetrendinincidenceofnsCLPWaSobservedduring1997—2006Familyhistoryearlypregnancydrug，passivesmokingandbirthweightageriskfa