酰基硫脲、酰氨基硫脲的綠色合成研究.pdf

1、西北師范大學(xué)碩士學(xué)位論文?；螂?、酰氨基硫脲的綠色合成研究姓名：張彰申請學(xué)位級別：碩士專業(yè)：有機化學(xué)指導(dǎo)教師：王喜存李政20050501AbstractAcylthioureaandthiosemicarbazideshaveextensivebiologicalactivitiessuchasantibacterial，antihypertension，anticonvulsive，antidepressant，localanaest

2、hesialocal，insecticideandplantgrowthregulatoractivitiesThereforetheyhavebeenappliedtomanyfields，forinstance，medicine，agronomybiologyandSOonInaddition，furoylderivativesfrequentoccurrenceinnatureareofinterestbecauseoftheir

3、widerangeofbiologicaleffectsfortheoxygenatomoffuran—ringcomingintobeingthehydrogenbondseasilyandincreasingtheaffinityintheorganismsAsiffuroylmadAcylthioureaorthiosemicarbazideswerebroughtintoonemainbodymorecomprehensivee

4、fficiencycouldbeopenedoutInthemainportionofthisthesisGreenchemistryCleantechnologyandtheirapplicationsforsynthesiscompoundswhichweretosayarediscussedwedesignedandsynthesized58acylthioureaandthiosemicarbazidescompoundsinc

5、ludingin5seriesThemostofthempossessedoffuran—ringTheslaucturesofallthecompoundswereconformedbyElementalAnalysis，IRand1HNMRSeriesI～III：NarylN／【5一(2／nitrophenyl)一2furoyl]thiouleas，1aryloxyacetyl4一[5／(2Cnitrophenyl)一2／furoy

6、l]thiosemicarbazidesandNarylN／[2benzo(b)furyl]thioureasCanbeexpeditiouslysynthesizedbyonepotgrindingprocedureundersolventfreeandcatalysisconditioninexcellentyieldThefeaturesofeasyhandlingandnoneedofanyhazardoussolventsma

7、kethisprotocolmoresuitabletOcombinatorialsynthesisandindustrialapplicationsSeriesIV～V：One—stepsynthesisofNarylNLaroylthiouleasand1aroyl4[27benzo(b)furancarbonyl]thiosemicarbazidesinaqueousmediainthepresenceofTEBAcatalyst

8、comparedwithconventionalsynthesismethodsThesynthesisinaqueouscombinetwostepsintooneandthehandlingbecomemorgbriefnessItismoleimportantthatthefree—solventdesignandinaqueousmediarouteareallbasedOilthegreen—chemistryandavoid

9、edthepollutionofenvironmentThesectiontowofthethesisisgoingtodiscussthesilvermirrorreactionofaminesandsilvernitrate，drawingtheconclusionthatsilvernitratesolutioncouldactasthedifferentiatingreagentofaminesanddifferentamine